Close

Automated protein crystallography
for new structures and small
molecule screening

Services

All our services include access to fully automated, remote-controlled
protein-to-structure pipelines based on the innovative technologies
CrystalDirect™ and CRIMS developed at EMBL.

Online
Crystallography

Establishing new crystal systems for challenging targets.

Online
Crystallography

Establishing new crystal systems for challenging targets.

Ultra-fast compound structural analysis

Parallel screening of compounds to support MedChem and structure-based drug design.

Ultra-fast compound structural analysis

Parallel screening of compounds to support MedChem and structure-based drug design.

Automated fragment screening

High-throughput, state-of-the-art fragment screening, covering a highly diverse chemical space – libraries provided by the client or ALPX.

Automated fragment screening

High-throughput, state-of-the-art fragment screening, covering a highly diverse chemical space – libraries provided by the client or ALPX.

Data collection and structure solution

X-ray data collection of crystals at multiple synchrotrons and structure solution of biomolecules, including ligand and binding site refinement.

Data collection and structure solution

X-ray data collection of crystals at multiple synchrotrons and structure solution of biomolecules, including ligand and binding site refinement.

CrystalDirect™

Taking crystallography to the next level through automation

A fully automated technology for processing and harvesting of crystals, based on laser-induced photoablation.

  • High-throughput automated crystal harvesting
  • Suitable for all crystal morphologies
  • Crystal surgery
  • Automated, gentle diffusion of ligands, increasing crystal tolerance to organic solvents
  • Serial crystallography experiments in standard and lipidic cubic phase media

CRIMS

The Crystallographic Information
Management System

An interactive online software suite that tracks experiments and results, and makes them available to scientists in real-time through intuitive interfaces.

Features

  • Remote-controlled web-based workflows, from pure protein to refined structures
  • Automated synchronised data transfer to synchrotrons (multiple sites supported)
  • Integration with the expert system Pipedream (GLPhL) for rapid and efficient automated data processing, refinement, ligand identification, ranking, and validation

About ALPX

ALPX is an EMBL spin-off, based at the European Photon Neutron campus in

Grenoble, France. It provides structural biology services and expertise

to pharmaceutical and biotech companies to accelerate

the drug discovery process.

Contact us